Analysis of KIR genotyping results in women with recurrent implantation failure

نویسندگان

چکیده

Aim. To analyze the frequency and distribution of KIR genotypes in women with recurrent implantation failure after cycles vitro fertilization. Methods. DNA extraction purification, PCR-SSP, agarose gel electrophoresis. Results. The spectrum genes were determined. study group was divided according to history, particular, a 84 whose diagnosis outlined by concept "repeated failed implantations" singled out. Statistical analysis obtained results using Pearson test (χ2) indicates significantly lower KIR-AB genotype (χ2 = 9.7; p < 0.005) higher KIR-AA 7.35; 0.01) repeated implantations compared general reproductive failures. Conclusions. Taking into account statistical data processing (OR 2.05; CI 95 %: 1.21-3.45), we consider be significant risk factor for IVF. We define genotyping as genetic assess embryo being rejected maternal immune system, thus direct medical interventions order achieve successful pregnancy.

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ژورنال

عنوان ژورنال: Faktori eksperimental?noï evolûcìï organìzmìv

سال: 2023

ISSN: ['2219-3782', '2415-3826']

DOI: https://doi.org/10.7124/feeo.v33.1572